PrEP is a highly effective bio-behavioral intervention that, if brought to scale, may reduce HIV incidence among at-risk populations. A PrEP package of services extends beyond medication prescribing and clinical monitoring to include STI screening, benefits navigation, risk reduction and adherence counseling, condom provision, partner services, and other wrap-around support. PrEP can be delivered “under one roof” or involve collaborations between health departments (HDs), community-based and health care organizations (CBOs/HCOs). This workshop will feature four PrEP delivery models that seek to reach MSM of color, cis- and transgender women, and adolescents: a federally qualified health center closely linked to a large city HD (Howard Brown Health, Chicago); a municipal STI clinic (Fulton County, GA); a reproductive health clinic (HIVE, San Francisco); and a community-based AIDS Service Organization (Philadelphia Fight). A moderated panel and interactive breakout session will encourage participants to draw cross-cutting lessons from these programs’ successes and ongoing challenges.